Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
نویسندگان
چکیده
منابع مشابه
Induction of allergen-specific blocking IgG using patch delivered recombinant Bet v 1 in guinea pigs
Background Allergen-specific immunotherapy (SIT) is the only specific, disease-modifying treatment for allergy and may have long-lasting effects. It is given traditionally in the form of multiple subcutaneous injections which makes the treatment inconvenient. Furthermore, systemic allergenadministration may cause severe side effects. Therefor the development of alternative routes for SIT has be...
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چکیده ندارد.
15 صفحه اولAnalysis of potential immunoglobulin E epitopes of Gly m 4, a bet V 1-related allergen in soy beans
Binding and crosslinking of FcåRI-bound IgE to conformational epitopes on allergens causes hypersensitivity reactions in allergic patients. The knowledge and modulation of epitopes on the molecular level allows the design of both hypoallergenic recombinant variants of the allergen and specific antibodies for therapeutic and diagnostic purposes, respectively. We sought to identify and analyze th...
متن کاملFolded or Not? Tracking Bet v 1 Conformation in Recombinant Allergen Preparations
BACKGROUND Recombinant Bet v 1a (rBet v 1a) has been used in allergy research for more than three decades, including clinical application of so-called hypoallergens. Quantitative IgE binding to rBet v 1a depends on its native protein conformation, which might be compromised upon heterologous expression, purification, or mutational engineering of rBet v 1a. OBJECTIVE To correlate experimental/...
متن کاملNMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1
In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 occurs as a mixture of various isoforms that possess different immunological p...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2016
ISSN: 1940-087X
DOI: 10.3791/54721